Vortioxetine-fluoxetine

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from vortioxetine to fluoxetine.

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 8: stop administration of vortioxetine.
Eenrichtingbord.png Start fluoxetine
  • A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.
  • Day 23: start administration of fluoxetine in a normal dosage of 20 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.

[1][2]

  1. ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
  2. ↑ KNMP; Informatorium Medicamentorum 2015; Monografie "vortioxetine" (Dutch)
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