Switch medication from vortioxetine to fluoxetine.
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
- A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.
- Day 23: start administration of fluoxetine in a normal dosage of 20 mg/day.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- KNMP; Informatorium Medicamentorum 2015; Monografie "vortioxetine" (Dutch)
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