Switch medication from vortioxetine to dosulepine.
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
- Day 9: start administration of dosulepine with 25 mg/day.
- Titrate slowly
- Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
- ↑ NVZA; Toxicology.org; Monografie 63 (dutch)
- ↑ European Medicines Agency | SmPC Brintellix 5 mg.
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