Switch medication from vortioxetine to dosulepine.[2][3]
Stop vortioxetine
-
Day 1: Stop vortioxetine
- vortioxetine can be stopped abruptly[4]
Start dosulepine
-
Day 1: Increase with about 25% of target dose per 3 days.
More information
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
-
↑ NVZA; Toxicology.org; Monografie 63 (dutch)
-
↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
-
↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
-
↑ CBG meb, accessed june 2023, SmPC Vortioxetine
-
↑ (dutch) monografie.org tricyclische-antidepressiva
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