Vortioxetine-dosulepine

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from vortioxetine to dosulepine.

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 8: stop administration of vortioxetine.
Eenrichtingbord.png Start dosulepine
  • Day 9: start administration of dosulepine with 25 mg/day.
  • Titrate slowly
  • Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[3]
  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
  2. ↑ NVZA; Toxicology.org; Monografie 63 (dutch)
  3. ↑ European Medicines Agency | SmPC Brintellix 5 mg.
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