Vortioxetine-agomelatine

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from vortioxetine to agomelatine.[1][2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: Stop vortioxetine
  • vortioxetine can be stopped abruptly[3][4]
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[5]
  • If necessary, increase dosage of agomelatine to 50 mg/day.
Infobord.png More information
  1. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. ↑ CBG meb, accessed june 2023, SmPC Vortioxetine
  4. ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
  5. ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
  6. ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
  7. ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
  8. ↑ Summary of Product Characteristics Vortioxetine
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