Switch medication from venlafaxine to tranylcypromine.[1][2]
Stop venlafaxine
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Before day 1: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
-
Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
-
Day 8: stop administration of venlafaxine.
- Stop and wait 5 days for washout
Start tranylcypromine
- a wash-out period of 5 days is necessary.
- Start tranylcypromine in a low dosage of 20 mg/day for one week.
- After this week the dosage of tranylcypromine can be increased.
Cave
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↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
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↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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