Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Type Antidepressant
Group SSRI
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from tranylcypromine to fluoxetine.[1][2]

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1: decrease the original dose with about 25% every 3 days.
  • Day 9: stop administration of tranylcypromine.
Eenrichtingbord.png Start fluoxetine
  • Day 23 and after: start fluoxetine at 100% of the target dose.[3]
  • After 3 weeks: If necessary, gradually increase dosage of fluoxetine.
Infobord.png More information
  • Occurrence of the serotonin syndrome is possible without this wash-out period.
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[3]
  • Tranylcypromine has to be phased out to avoid withdrawal symptoms.[4]
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. 3.03.1 KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
  4. Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers
  5. (dutch) tricyclische-antidepressiva
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