Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine
Type Antidepressant
Group TCA
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from tranylcypromine to amitriptyline.[1][2]

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1: decrease the original dose with about 25% every 3 days.
  • Day 9: stop administration of tranylcypromine.
Eenrichtingbord.png Start amitriptyline
  • Day 23: Start and increase the dose with about 25% of the target dose every 3 days. [3]
Letopbord.png Cave
Infobord.png More information
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[3]
  • Tranylcypromine has to be phased out to avoid withdrawal symptoms.[4]
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. 3.03.1 KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
  4. Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers
  5. (dutch) tricyclische-antidepressiva
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