Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine
Type Antidepressant
Group other
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from tranylcypromine to agomelatine.

Nietinrijdenbord.png Stop tranylcypromine
  • Day 1-14: decrease the original dose with about 25% every 3 days.
Eenrichtingbord.png Start agomelatine
  • Day 15: Start and increase the dose with about 25% of the target dose every 3 days or 50% per week.[1]
Infobord.png More information
  • Tranylcypromine has to be phased out to avoid withdrawal symptoms.
  • After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
  1. KNMP; Informatorium Medicamentorum 2015; Monografie "tranylcypromine" (Dutch)
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