Switch medication from tranylcypromine to agomelatine.
- Day 1-14: decrease the original dose with about 25% every 3 days.
- Day 15: Start and increase the dose with about 25% of the target dose every 3 days or 50% per week.
- Tranylcypromine has to be phased out to avoid withdrawal symptoms.
- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
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