Switch medication from Sulpiride to Paliperidone.
Stop Sulpiride
-
Day 1-4: approx. 75% of initial dose
-
Day 5-8: approx. 50% of initial dose
-
Day 9-12: approx. 25% of initial dose
-
Day 13: stop
Start Paliperidone
-
Day 1-4: approx. 25% of target dose
-
Day 5-8: approx. 50% of target dose
-
Day 9-12: approx. 75% of target dose
-
Day 13: target dose
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[1]
— Sulpiride
— Paliperidone
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