- In general after long-term maintenance treatment, the best is to reduce the dose by about 25% every 4-6 weeks. An apt pharmaceutical dose (tablet, capsule, mixture) is not always available. In these cases one should be creative with dosing.
- Another, more risky, possibility is being at a certain dose to use the following scheme:
- 300 mg/day :
- Day 1: reduce dosage of moclobemide to 150 mg/day.
- Day 15: reduce dosage of moclobemide to 75 mg/day.
- Day 29: stop the administration of moclobemide.
- The UK Drug and Therapeutics Bulletin; 1999;37:49-52
- Editor: please note that not all dosages are available in pharmacy. So now and then you should be creative.
- Bazire S, Psychotropic Drug Directory 2010. Aberdeen: HealthComm UK Ltd; 2010.
- Curtin F et al. Moclobemide discontinuation syndrome predominantly presenting with influenza-like symptoms. J Psychopharmacol. 2002 Sep;16(3):271-2
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