Switch medication from sertraline to fluvoxamine.
Stop sertraline
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Before day 1: Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
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Day 1: Reduce dosage of sertraline to a dosage of 25 mg/ day
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Day 8: Stop administration of sertraline
Start fluvoxamine
- No wash-out period is needed.
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Day 9: start fluvoxamine in normal dosage of 50 mg/day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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