Switch medication from sertraline to agomelatine.
- Before day 1: Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: Reduce dosage of sertraline to a dosage of 25 mg/ day
- Day 8: Stop administration of sertraline
- Day 9: start agomelatine in a dosage of 25 mg/day.
- Day 16: if necessary, gradually increase dosage of agomelatine to target dose.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
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