Switch medication from Partial agonist to Clozapine.
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.
Stop Partial agonist
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Day 1-21: Continue drug at usual dose
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Day 22: Stop drug
Start Clozapine
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Day 1: start with 12,5 mg at night
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Day 2: 25 mg in divided doses
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Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
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Day 16-28: if necessary, increase dose with 50-100 mg/week
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[1]
— Partial agonist
— Clozapine
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