Switch medication from paroxetine to venlafaxine.
Stop paroxetine
-
Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
-
Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
-
Day 8: stop administration of paroxetine.
Start venlafaxine
- No wash-out period is needed.
-
Day 9: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine slows the metabolism of venlafaxine via CYP2D6.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
