Switch medication from paroxetine to dosulepine.
Stop paroxetine
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Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
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Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
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Day 8: stop administration of paroxetine.
Start dosulepine
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Day 9: start administration of dosulepine in a low dosage of 50 mg/day.
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Day 16: increase administration of dosulepine.
More information
- Paroxetine possibly slows the metabolism of dosulepine via CYP2D6.
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