Switch medication from paroxetine to bupropion.
Stop paroxetine
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Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
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Day 0: dosage of paroxetine is 20 mg/day.
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Day 1: reduce dosage of paroxetine to 10 mg/day.
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Day 8: reduce dosage of paroxetine to 5 mg/day.
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Day 15: stop administration of paroxetine.
Start bupropion
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Day 16: start bupropion is a normal dosage of 150 mg/day.
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Day 31: if necessary increase bupropion to 300 mg/day.
More information
- An extra reduction week to paroxetine 2,5 mg/day sometimes is necessary.
- Low doses of paroxetine can be given by a paroxetine-solution.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
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