Paroxetine-amitriptyline

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from paroxetine to amitriptyline.[1][2]

Nietinrijdenbord.png Stop paroxetine
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start amitriptyline
  • Day 1: start administration of amitriptyline in a low dosage of 25mg/day.
  • Day 8: increase dosage of amitriptyline to a dosage of 50 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of amitriptyline via CYP2D6 inhibition.
  • Due to CYP inhibition a longer period of time is needed to reach steady state concentration. Please keep in mind when monitoring plasma levels
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. ↑ (dutch) monografie.org tricyclische-antidepressiva
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