Switch medication from Paliperidone to Sertindole.
Stop Paliperidone
-
Day 1-4: approx. 75% of initial dose
-
Day 5-8: approx. 50% of initial dose
-
Day 9-12: approx. 25% of initial dose
-
Day 13: stop
Start Sertindole
-
Day 1-4: approx. 25% of target dose
-
Day 5-8: approx. 50% of target dose
-
Day 9-12: approx. 75% of target dose
-
Day 13: target dose
Cave
- During this switch ECG monitoring is required because of possible QT-interval prolongation[1][2]
More information
— Paliperidone
— Sertindole
-
↑ SPC Sertindole (Dutch)
-
↑ SPC Sertindole
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