Paliperidone ER-Partial agonist

* This switch is intended for paliperidone long acting (Xeplion®, 30 days)

There are 3 different formulations of paliperidone extended release

Xeplion® = Paliperidone long acting / 30 days

Trivecta® = Paliperidone super long acting / 90 days

Byannli® = Paliperidone ultra long acting / 178 days

Partial agonists

Aripiprazole
Brexpiprazole
Cariprazine

Switch medication from Paliperidone ER to Partial agonist.
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.

Nietinrijdenbord.png Stop Paliperidone ER
  • Day 1: Last depot injection
Eenrichtingbord.png Start Partial agonist
  • Start drug at target dose on the day you would normally have injected the next depot.
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
    StopDepotStartArip.jpg
Nietinrijdenbord.png — Paliperidone ER
Eenrichtingbord.png — Partial agonist


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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