Switch medication from Olanzapine to Partial antagonist.
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.
Stop Olanzapine
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Week 1: approx. 75% of initial dose
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Week 2: approx. 50% of initial dose
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Week 3: approx. 25% of initial dose
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Week 4: approx. 12,5% of initial dose
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Day 28: stop
Start Partial antagonist
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Day 1-3: start 50% of target dose
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Day 4-7: target dose
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[4]
— Olanzapine
— Partial antagonist
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