Switch medication from moclobemide to trazodone.
- Decrease with about 25% of original dose every 3 days
- Stop and wait for about 24 hour as a washout period
- Start with the initial dose
- Because of short halve life of moclobemide after stopping, the next antidepressant can start next day.
- A wash-out period of is not necessary.
- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
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