Switch medication from moclobemide to duloxetine.[1][2]
Stop moclobemide
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Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
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Day 1: reduce the dosage of moclobemide to 150 mg/day.
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Day 8: stop administration of moclobemide.
Start duloxetine
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Day 9: Increase with about 25% of target dose per 3 days.
More information
- Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[3]
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↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
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↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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↑ Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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