- Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
- Day 1: reduce the dosage of moclobemide to 150 mg/day.
- Day 8: stop administration of moclobemide.
- Day 9: Increase with about 25% of target dose per 3 days.
- Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.
- KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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