Switch medication from imipramine to paroxetine.
Stop imipramine
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Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
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Day 1-3: reduce dosage of imipramine to 50 mg/day.
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Day 4-7: reduce dosage of imipramine to 25 mg/day.
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Day 8: stop administration of imipramine.
Start paroxetine
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Day 4: simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
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Day 8: stop administration of imipramine and continue administration of paroxetine.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine.
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