Type Antidepressant
Group TCA
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Type Antidepressant
Group NRI
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from imipramine to maprotiline.

Nietinrijdenbord.png Stop imipramine
  • Before day 1: Gradually reduce dosage of imipramine to a maximum of 50-100 mg/day.
  • Day 1: when a dosage of 50-100 mg/day is reached, stop administration of imipramine
Eenrichtingbord.png Start maprotiline
  • No wash-out period is needed.
  • Day 2: start administration of maprotiline in a normal dosage of 25-75 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
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