Switch medication from imipramine to fluvoxamine.
Stop imipramine
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Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
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Day 1-3: reduce dosage of imipramine to 50 mg/day.
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Day 4-7: reduce dosage of imipramine to 25 mg/day.
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Day 8: stop administration of imipramine.
Start fluvoxamine
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Day 4: simultaneously start administration of fluvoxamine in a normal dosage of 50 mg/day.
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Day 8: stop administration of imipramine and continue administration of fluvoxamine in a dosage of 50-100 mg/day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize imipramine.
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