- Day 1: Decrease with about 25% of the original dose per 3 days.
- No wash-out period is needed.
- Day 1: Increase with about 25% of target dose per 3 days.
- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.
- Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- (dutch) monografie.org tricyclische-antidepressiva
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