Haloperidol-Quetiapine
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Switch medication from Haloperidol to Quetiapine.
Stop Haloperidol
- Day 1-4: approx. 75% of initial dose
- Day 5-8: approx. 50% of initial dose
- Day 9-12: approx. 25% of initial dose
- Day 13: stop
Start Quetiapine
- Day 1-4: approx. 25% of target dose
- Day 5-8: approx. 50% of target dose
- Day 9-12: approx. 75% of target dose
- Day 13: target dose
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[8]
— Haloperidol
— Quetiapine
— Quetiapine
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01
-
↑ 2.02.12.22.32.42.5 KNMP; Informatorium Medicamentorum 2015; Monografie "haloperidol" (Dutch)
Cite error: Invalid
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tag; name "informatorium" defined multiple times with different content - ↑ 3.03.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ 4.04.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)
- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ Drugs.com quetiapine-fumarate
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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