Haloperidol LA-Olanzapine

Haloperidol
long acting
Type Antipsychotic
Group Butyrophenones
links
ATC-code N05AD01
Medscape Haloperidol
PubChem 3559
PubMed Haloperidol
Drugs.com haloperidol
Kompas (Dutch) Haloperidol
Wikipedia Haloperidol
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Switch medication from Haloperidol_LA to Olanzapine.

Nietinrijdenbord.png Stop Haloperidol_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Olanzapine
  • Week 1-3: approx. 25% of target dose
  • Week 4-6: approx. 50% of target dose
  • Week 7-9: approx. 75% of target dose
  • Week 10: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[7]
    StopDepotStartOral.jpg
Nietinrijdenbord.png — Haloperidol_LA
Eenrichtingbord.png — Olanzapine


  1. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01
  2. ↑ 2.02.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  3. ↑ 3.03.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)
  4. ↑ 4.04.14.24.3 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
  5. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  6. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  7. ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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