Switch medication from fluvoxamine to moclobemide.
Stop fluvoxamine
- Decrease with about 25% of original dose every 3 days
- Stop and wait 7 days for washout
Start moclobemide
- Start at the first day after the washout week with about 25% of target dose.
Cave
- Occurrence of the serotonin syndrome is possible without wash-out period.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
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