Fluvoxamine-duloxetine

Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from fluvoxamine to duloxetine.

Nietinrijdenbord.png Stop fluvoxamine
  • Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of fluvoxamine further to 25 mg/day.
  • Day 8: stop administration of fluvoxamine.
Eenrichtingbord.png Start duloxetine
  • Day 9: start duloxetine 30 mg/day.
  • Day 18: increase administration of duloxetine to 60 mg/day.
Infobord.png More information
  • Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2.[1]
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. ↑ Lobo et al. In vitro and in vivo evaluations of cytochrome P450 1A2 interactions with duloxetine. Clin Pharmacokinet. 2008;47(3):191-202
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