Switch medication from Flupenthixol_LA to Clozapine.
Stop Flupenthixol_LA
-
Day 1: Last depot injection
Start Clozapine
-
Day 1-3: start with 12,5 mg at night
-
Day 4-6: 25 mg in divided doses
-
From day 7: increase daily dose every 3-4 day(s) with 25 mg
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[1]
— Flupenthixol_LA
— Clozapine
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