Fluoxetine-maprotiline
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Switch medication from fluoxetine to maprotiline.
Stop fluoxetine - Reduce the dosage to 20mg/day and then stop the administration
Start maprotilineCaution is necessary for at least four weeks.
- Day 2: start administration of maprotiline in a low dosage of 25 mg/day.
- Day 15: increase dosage of maprotiline to 50 mg/day.
- Day 29: gradually increase dosage of maprotiline to 75 mg/day and more.
More information- Fluoxetine and norfluoxetine slow the metabolism of maprotiline via CYP2D6.
- Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
- Start low, go slow for maprotiline.
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