Fluoxetine-doxepine

Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin

Switch medication from fluoxetine to doxepin.

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Eenrichtingbord.png Start doxepin

Caution is necessary for at least four weeks.

  • Day 2: start administration of doxepin in a low dosage of 25 mg/day.
  • Day 15: increase dosage of doxepin to 50 mg/day.
  • Day 29: increase dosage of doxepin to 75 mg/day.
Infobord.png More information
  • Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Start low, go slow for doxepin.
  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2015; Monografie "doxepine" (Dutch)
  2. ↑ NVZA; Toxicology.org; Monografie 63 (dutch)
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