Switch medication from duloxetine to maprotiline.
- Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
- Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
- Day 8: stop administration of duloxetine.
No wash-out period is needed.
- Day 8: start administration of maprotiline in a low dosage of 25 mg/day.
- Day 15: increase the dosage of maprotiline to 50 mg/day.
- Duloxetine slows the metabolism of maprotiline by CYP2D6.
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