Doxepine-duloxetine

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from doxepin to duloxetine.[3][4]

Nietinrijdenbord.png Stop doxepin
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start duloxetine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose duloxetine = 60 mg
  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. ↑ NVZA; Toxicology.org; Monografie 63 (dutch)
  3. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  4. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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