Switch medication from dosulepine to hypericum.
- Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 8: reduce dosage of dosulepine to 25 mg/day.
- Day 15: stop administration of dosulepine.
- Day 15-22: a wash-out period of one week is necessary.
- Day 23: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
- Occurrence of the serotonin syndrome is theoretically possible without wash-out period.
- Hypericum induces enzymes of the CYP P-450 type and P-gp type.
- Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
- Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.
- The T1/2 of hypericum is 19 - 37 hour.
↑ 1.01.11.21.31.41.5 KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
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- ↑ NVZA; Toxicology.org; Monografie 63 (dutch)
- ↑ Wurglics M, Schubert-Zsilavecz M.Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.
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