Combining-Ziprasidone-Carbamazepine

Ziprasidone
Type Antipsychotic
Group Atypical AP
Other use Moodstabilizer
links
Medscape Ziprasidone
PubChem 60854
PubMed Ziprasidone
Wikipedia Ziprasidone
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to ziprasidone.

Infobord.png General information
  • Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects.
  • Induction of CYP3A4 by carbamazepine may modestly influence the plasma level of ziprasidone. Ziprasidone dose modifications are unlikely to be necessary in patients receiving potent CYP450 3A4 inducers.[5]
Eenrichtingbord.png Start carbamazepine
  • Start carbamazepine according to the general dosing advice.



  1. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. ↑ KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch)
  5. ↑ Interactions between ziprasidone and carbamazepine on drugs.com
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