Adding ziprasidone to aripiprazole.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Agents with anticholinergic properties may have additive effects when used in combination.
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