Combining-Valproic acid-Topiramate

Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid
Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate

Adding topiramate to valproic acid.

Infobord.png General information
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
Eenrichtingbord.png Start topiramate
  • Start topiramate according to general dosing advice. Pharmacologic response to the drugs should be monitored more closely following addition or withdrawal of one or the other drug. [4]
Letopbord.png Cave
  • Topiramate has been shown to produce a small but significant increase in valproate clearance, reducing plasma levels.
  • Topiramate plasma levels are increased by about 15% by valproate, which could be important if valproic acid is withdrawn.[5]


  1. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  2. ↑ 2.02.12.2 Farmacotherapeutisch Kompas - valproinezuur (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  3. ↑ KNMP; Informatorium Medicamentorum 2015; Monografie "valproaat" (Dutch)
  4. ↑ Interactions between valproic acid and topiramate on drugs.com
  5. ↑ Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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