Combining-Valproic acid-Risperidone

Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to valproic acid.

Infobord.png General information
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).

 

Eenrichtingbord.png Start risperidone
  • Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
  • Start according to the general dosing advice. Monitoring of the pharmacologic response and serum valproate levels is recommended.[6]
Letopbord.png Cave
  • Dose-related generalised oedema is reported. [7]
  • Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. [8]


  1. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  2. ↑ Farmacotherapeutisch Kompas - valproinezuur (dutch)
  3. ↑ 3.03.13.2 KNMP; Informatorium Medicamentorum 2015; Monografie "valproaat" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  4. ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  5. ↑ 5.05.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  6. ↑ Interactions between risperidone and valproic acid on drugs.com
  7. ↑ Sanders and Lehrer, Edema associated with addition of risperidone to valproate treatment. J Clin Psychiatry. 1998 Dec;59(12):689-90.
  8. ↑ Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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