Adding quetiapine to valproic acid.
General information
- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. [7]
Start quetiapine
- Start quetiapine according to the general dosing advice.
Cave
- During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. [8]
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