Combining-Topiramate-Lamotrigine

Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to topiramate.

Infobord.png General information
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start lamotrigine
  • Topiramate does not cause a significant change in lamotrigine levels. [4] Start topiramate according to the general dosing advice.



  1. ↑ 1.01.11.2 Farmacotherapeutisch Kompas - topiramaat (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ Drugs.com lamotrigine
  4. ↑ Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23
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