Combining-Risperidone-Ziprasidone

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Ziprasidone
Type Antipsychotic
Group Atypical AP
Other use Moodstabilizer
links
Medscape Ziprasidone
PubChem 60854
PubMed Ziprasidone
Wikipedia Ziprasidone

Adding ziprasidone to risperidone.

Infobord.png General information
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
Eenrichtingbord.png Start ziprasidone
  • The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Letopbord.png Cave
  • The concurrent use of ziprasidone with other medications that can prolong the QT interval is considered contraindicated.[4]


  1. ↑ 1.01.1 KNMP; Informatorium Medicamentorum 2015; Monografie "risperidon" (Dutch)
  2. ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  3. ↑ 3.03.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  4. ↑ Interactions between risperidone and ziprasidone on drugs.com
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