Adding carbamazepine to quetiapine.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
- Start carbamazepine according to the general dosing advice.
- The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.
- Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. 
↑ 1.01.11.21.3 KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch)
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- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ Drugs.com quetiapine-fumarate
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
- ↑ Interactions between carbamazepine and quetiapine on drugs.com
- ↑ Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91
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