Adding aripiprazole to quetiapine.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Agents with anticholinergic properties may have additive (side)effects when used in combination. 
- ↑ 1.01.11.2 KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch)
- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ Drugs.com quetiapine-fumarate
- ↑ Interactions between quetiapine and aripiprazole on drugs.com
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