Combining-Olanzapine-Valproic acid

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid

Adding valproic acid to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start valproic acid
  • Start valproic acid according to the general dosing advice. Monitoring of the liver function every 3 to 4 months during the first year of treatment with either olanzapine or valproic acid is recommended.[5]
Letopbord.png Cave
  • Concurrent use of olanzapine and valproic acid may potentiate the risk of hepatotoxicity.[5]


  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. ↑ 2.02.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid <ref> tag; name "ftktox" defined multiple times with different content
  3. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. ↑ Farmacotherapeutisch Kompas - valproinezuur (dutch)
  5. ↑ 5.05.1 Interactions between olanzapine and valproic acid on drugs.com
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