Adding risperidone to olanzapine.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Agents with anticholinergic properties may have additive effects when used in combination. 
↑ 1.01.11.21.31.41.5 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
Cite error: Invalid
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- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 5.05.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Interactions between risperidone and olanzapine on drugs.com
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