Combining-Olanzapine-Risperidone

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
Eenrichtingbord.png Start risperidone
  • The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Letopbord.png Cave
  • Agents with anticholinergic properties may have additive effects when used in combination. [6]


  1. ↑ 1.01.11.21.31.41.5 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  5. ↑ 5.05.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  6. ↑ Interactions between risperidone and olanzapine on drugs.com
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