Combining-Olanzapine-Quetiapine

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding quetiapine to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
Eenrichtingbord.png Start quetiapine
  • The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
Letopbord.png Cave
  • Agents with anticholinergic properties may have additive effects when used in combination. [7]


  1. ↑ 1.01.11.21.31.41.51.6 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
  5. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  6. ↑ Drugs.com quetiapine-fumarate
  7. ↑ Interactions between olanzapine and quetiapine on drugs.com
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