Combining-Olanzapine-Lamotrigine

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine

Adding lamotrigine to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start lamotrigine
  • Start lamotrigine according to the general dosing advice.
Letopbord.png Cave
  • Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine.

[5]


  1. ↑ 1.01.11.21.3 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
  2. ↑ 2.02.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid <ref> tag; name "ftktox" defined multiple times with different content
  3. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
  5. ↑ 5.05.1 Drugs.com lamotrigine Cite error: Invalid <ref> tag; name "drugscom" defined multiple times with different content
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