Combining-Olanzapine-Carbamazepine

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to olanzapine.

Infobord.png General information
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Consider alternative for carbamazepine, otherwise start carbamazepine according to the general dosing advice.
  • Check clinical effect or olanzapine plasma concentration after 2 weeks and adapt dose if necessary. [6][7]
Letopbord.png Cave
  • Close clinical monitoring for evidence of altered olanzapine effect is recommended in patients receiving carbamazepine.


  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  2. ↑ 2.02.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid <ref> tag; name "ftktox" defined multiple times with different content
  3. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  5. ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
  6. ↑ Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
  7. ↑ Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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